Mifepristone

Mifepristone Mechanism:

Mifepristone is an oral medication that serves as an anti-progestin, effectively blocking the hormone progesterone, which is essential for sustaining pregnancy. By binding to progesterone receptors, it halts the supply of oxygen and nutrients to the developing embryo, ultimately leading to its demise. This mechanism of action allows Mifepristone to be a crucial part of medical abortion regimens, especially when used in combination with Misoprostol to facilitate the expulsion of the fetus.

Mifepristone Contraindications:

Mifepristone is contraindicated in specific conditions, including ectopic pregnancies and pregnancies exceeding 63 days. Individuals should avoid using this medication if they have a known allergy to Mifepristone or its components, as well as in cases of unusual bleeding disorders or adrenal insufficiency. Pregnant or breastfeeding women should not take this medication.

Drug Interactions:

When taking Mifepristone, it's essential to avoid certain medications, such as:

• Anticonvulsants like phenobarbital, phenytoin, and carbamazepine
• Anticoagulants such as Warfarin
• Antifungal medications including itraconazole, ketoconazole, and erythromycin

Store Mifepristone in a cool, dry place, away from excessive light, heat, and moisture. Keep it out of reach of children and pets.

Dosage of Mifepristone:

The recommended dosage for Mifepristone is three tablets of 200 mg each, taken orally with water to terminate an intrauterine pregnancy of less than 63 days. Following this, a follow-up visit to a healthcare provider is essential after two days to confirm the completion of the abortion. In cases of incomplete abortion, an additional two tablets may be administered either orally or vaginally.

Reactions to Mifepristone:

Possible side effects include rapid heartbeat, nausea, vaginal bleeding, tenderness, vomiting, pelvic pain, and headaches. If any adverse symptoms persist or worsen, immediate medical attention is required. Patients should bring their prescription details to any healthcare visit, particularly if seeking emergency care, to inform providers of their medical abortion. Patients must also be aware of potential serious complications and know how to seek help in emergencies, including signs of heavy bleeding or persistent discomfort.